Assessing microvascular occlusion mediated by red blood cells
About
Microvasculature Mimicking
A gradient of microcapillary networks Side passageways mimicking the arteriovenous anastomoses
Circulatory Diseases
A universal parameter for assessment of RBC deformability in many circulatory diseases (RBC health gauge): Occlusion Index (OI)
Adhesion & Deformability
The OcclusionChip can be functionalized with adhesion proteins for simultaneous adhesion & deformability measurements
Sample
Isolated RBCs at near physiologic hematocrit level (20%)
TypicalUses
Clinical Assay, Personalized Medicine, Research, Drug Development
Targeted Therapies
Drugs that target RBC sickling/deformability (e.g., Voxelotor) in SCD
Curative Therapies
NHLBI-supported multisite study to assess RBC mediated microcapillary occlusions before and after a gene-based(2) therapy for curative intent(1).
References
Based on publications:
Lab on a Chip, 2020; Microcirculation, 2020
1.https://curesickle.org