Endothelium-on-a-Chip

Assessing blood cell adhesion to cultured endothelial cells.

About

Mimicking in vivo conditions

Provide more physiologically relevant environment compared to protein functionalized assays.

Endothelial cell type and source

Any type of primary human endothelial cells can be cultured under physiologic flow and activated via disease-specific pro-inflammatory agents.

Patient specific activation

Cultured endothelial cells can be activated via patients’ own blood and/or blood products.

Sample

Whole blood or isolated RBCs, WBCs, and platelets.

Typical
Uses

Clinical Assay, Personalized Medicine, Research, Drug Development

Targeted Therapies

Drugs that target RBC sickling/deformability (e.g., Voxelotor) in SCD.

Curative Therapies

NHLBI-supported multisite study to assess RBC mediated microcapillary occlusions before and after a gene-based therapy for curative intent(1).

References

Relevant Literature
AJH, 2018
BJH, 2020

1.https://curesickle.org

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